Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.
Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.
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Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.
This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.
What is Erectile Dysfunction?
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.
Signs and symptoms:
Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
Here are some causes of Erectile Dysfunction:
* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.
* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.
* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.
Physiology of normal erections:
Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.
Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.
Pathophysiology of erectile dysfunction:
Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.
Treatment:
Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.
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Kamagra (sildenafil) is a brand name for Ajanta Pharmacy Sildenafil Citrate. Tablets are available to buy in dosages of 100 milligrams. The pills are blue, rounded-diamond- shaped, film coated tablets in blister packs of four tablets.
Kamagra is a significant oral medication, generic version of Viagra, for the treatment of Erectile Dysfunction (ED). The medicine was originally developed as a cardiovascular medicine designed to improve blood flow in the vessels of the heart. However, during initial studies the medication was found to have a profound side effect: individuals began to report a remarkable difference in their ability to achieve and maintain an erection.
Further studies were completed and on March 27, 1998, the medication was approved by the FDA for the treatment of (ED), later that fall Kamagra was approved in the European Union and has since been approved by regulatory authorities in over 100 countries around the world.
Kamagra is dispensed as a pill and ingested orally. Within approximately 30-60 minutes the drug is absorbed into the bloodstream. Kamagra then functions as an inhibitor to an enzyme called phosphodiesterase type (PDE5) which is found primarily in the penis. By inhibiting PDE5, smooth muscle in the penis remains relaxed for a longer period. This allows for increased blood flow into the cavernous tissue of the penis thereby generating an erection.
Kamagra works with the natural chemicals of your body to give your penis an erection when you are sexually aroused. If you are not sexually aroused, Kamagra is not going to give you an erection.
What is the appropriate dose?
The standard dose is 50mg one hour prior to sexual activity. However, if you are older than age 65 or have a serious kidney or liver disease some physicians will recommend starting with the minimal dose of 25mg. Kamagra should not be taken more than once per any 24 hour period and doses should not exceed 100mg. The half-life of Kamagra, the time the drug remains effective after ingestion, is approximately four hours.
Kamagra is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median time 60 minutes) of oral dosing on an empty stomach. Please note: when Kamagra is taken with a high fat content meal, the rate of effectiveness can be significantly diminished.
What are the side effects of Kamagra?
Like all medications, Kamagra can cause some side effects. These are usually mild & tolerable and don't last longer than a few hours. Some of these side effects are more likely to occur with higher doses of kamagra.
The most common side effects experienced with Kamagra are:
headache
flushing
indigestion
stuffy nose
changes in vision such as blurring
a blue colour to your vision
diarrhoea
urinary tract infection
stomach upset
It's also worth remembering that if you suffer from side effects it is quite likely that you are taking too large a dose and reducing your dosage will reduce the side effects or even remove them altogether.
Medical advise should be sought immediately in the rare event of an erection lasting for more than 4hrs.
If you have chest pains, dizziness, or nausea during sex, stop and immediately tell your health care provider.
What precautions should be taken?
Kamagra must be used under doctors supervision. Kamagra must not be used by men who are taking any medications that contain nitrates. Nitrates are found in many prescription medications that are used to treat angina, such as Nitroglycerin, Isosorbide mononitrate (brand names: Monotrate, Vasotrate, Ismo, Imdur, Angicor), Isosorbide dinitrate (brand names: Sorbitrate, Isordil), Sublingual nitroglycerin tablets or spray (Angised, Angispan, GTN spray), Transdermal nitroglycerin patches or ointments (brand names: Top nitro, Nitroderm TTS, Myovin). Nitrates are also found in illicit drugs such as amyl nitrate (poppers). If you are not sure if any of your medicines contain nitrates, or if you do not understand what nitrates are ask you doctor or pharmacist. Kamagra is not approved for use in women.
There is also a potential for cardiac risk during sexual activity in patients with pre-existing cardiovascular disease. Therefore, Kamagra should NOT be used in men where sexual activity is inadvisable because of their underlying cardiovascular status.
The use of Kamagra offers no protection against sexually transmitted diseases, including HIV. Patients should continue to use protective measures necessary to guard against these diseases. In case of an overdose, call your physician immediately.
If you have ever suffered from any of the following conditions inform your doctor before taking Kamagra:
kidney / liver problems
heart conditions (e.g. irregular heart beat, chest pain, heart attack, angina or narrowing of the aortic valve)
high / low blood pressure
stroke
an inherited eye condition called retinitis pigmentose
any blood problems such as leukaemia or sickle cellanemia
penis deformity such as peyronies disease
an erection lasting more than 4 hours
allergy to Sildenafil
The consumption of alcoholic beverages can temporarily impair the ability to get and keep a sustained erection. To achieve maximum results while using Kamagra, you should not drink large amounts of alcohol before taking the medication.
For what types of Erectile Dysfunction is Kamagra proving to be especially effective?
Kamagra is showing optimal results in individuals who experience ED secondary to high levels of anxiety (performance anxiety) and individuals with mild ED.
Further studies were completed and on March 27, 1998, the medication was approved by the FDA for the treatment of (ED), later that fall Kamagra was approved in the European Union and has since been approved by regulatory authorities in over 100 countries around the world.
Can Kamagra be combined with other treatments for erectile dysfunction?
The use of such combined treatments is not recommended, since no studies have been done to access Kamagra's safety and effectiveness.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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